Rapid screening of high-priority N-nitrosamines in pharmaceutical, forensic, and environmental samples with paper spray ionization and filter cone spray ionization-mass spectrometry.
Trevor J McDanielJessica M HoltzEbenezer H BondzieMakoy OverfeltPatrick W FedickChristopher C MulliganPublished in: Rapid communications in mass spectrometry : RCM (2023)
PSI-MS and FCSI-MS were successful in detecting trace-level NAMS in complex liquid- and solid-phase matrices with little to no prior preparation. This work suggests that these methodologies can provide a means for assessing problematic pharmaceutical adulterants/degradants for expedited quality control, as well as enhancing environmental stewardship efforts and forensic investigations.
Keyphrases
- mass spectrometry
- gas chromatography
- quality control
- liquid chromatography
- capillary electrophoresis
- human health
- high performance liquid chromatography
- multiple sclerosis
- ms ms
- high resolution
- tandem mass spectrometry
- risk assessment
- heavy metals
- ionic liquid
- molecularly imprinted
- loop mediated isothermal amplification
- simultaneous determination
- climate change
- quantum dots