Exploring the catalytic role of the guanidine TBD in carboxylative cyclizations.
Kaitlin A IsfeldCharles KilleenDawson J KonowalchukRebecca L DavisPublished in: Organic & biomolecular chemistry (2022)
Employing a combination of mechanistic, kinetic and computational studies we have examined the mechanism of the TBD-catalyzed carboxylative cyclization of indole derivatives. Our studies provide insight into the role of the guanidine superbase TBD in catalyzing C-C bond formation between indole derivatives and CO 2 .