Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer.
Yi-Fang TsaiLing-Ming TsengChih-Yi HsuMuh-Hwa YangJen-Hwey ChiuYi-Ming ShyrPublished in: PloS one (2017)
Our study demonstrates that up-regulation of the BDNF signaling pathway seems tobe involved in the mechanism associated with early recurrence in triple negative breast cancer cell. In addition, BDNF can function in either an autocrine or a paracrine manner to increase the migration ability of both MDA-MB-231 cells and HUVEC cells. Finally, overexpression of TrkB, but not of BDNF, is significantly associated with a poor survival outcome for TNBC patients.
Keyphrases
- induced apoptosis
- cell cycle arrest
- signaling pathway
- stress induced
- endothelial cells
- end stage renal disease
- pi k akt
- endoplasmic reticulum stress
- ejection fraction
- chronic kidney disease
- cell death
- oxidative stress
- cell proliferation
- squamous cell carcinoma
- type diabetes
- free survival
- patient reported outcomes
- breast cancer cells
- skeletal muscle
- weight loss
- lymph node metastasis