A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.
Thomas G MartinDakota R HuntStephen J LangerYuxiao TanChristopher C EbmeierClaudia CrociniEunhee ChungLeslie A LeinwandPublished in: bioRxiv : the preprint server for biology (2024)
Post-prandial cardiac remodeling in Burmese pythons is associated with dynamic regulation of FoxO1 and autophagy.Regression of fed python plasma-induced hypertrophy in mammalian cardiomyocytes is FoxO1-dependent.Activation of FoxO1-dependent autophagy is a conserved feature of physiological hypertrophy regression in mammalian models.