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Less cholesterol means better tumor killing for cytotoxic T9 cells.

Brad GriesenauerSophie Paczesny
Published in: The Journal of experimental medicine (2018)
In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.
Keyphrases
  • low density lipoprotein
  • anti inflammatory