Short anagen hair syndrome: Association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.
Nicole CesaratoAgnes Schwieger-BrielYasmina GossmannSabrina K HenneKathrin HillmannLeonie H FrommherzMaria WehnerXing XiongHolger ThieleVinzenz OjiDonatella MilaniIliana Tantcheva-PoorKathrin GiehlRegina Fölster-HolstAnne TeichlerDelphine BraeckmansPeter H HoegerGabriela JonesJorge FrankLisa WeibelUlrike Blume-PeytaviHenning HammMarkus M NöthenMatthias GeyerStefanie Heilmann-HeimbachF Buket BasmanavRegina C BetzPublished in: The British journal of dermatology (2023)
Our results suggest that WNT10A is associated with SAH, and that SAH has a genetic overlap with the common phenotype MPHL. The presumed shared biological effect of WNT10A variants in SAH and MPHL is a shortening of the anagen phase. Other factors, such as modifier genes and sex, may also play a role in the clinical manifestation of hair phenotypes associated with the WNT10A locus.