Alashanines A-C, Three Quinone-Terpenoid Alkaloids from Syringa pinnatifolia with Cytotoxic Potential by Activation of ERK.
Shungang JiaoHuiming HuangLifang WangShana WukenChangxin LiuLulu KangJuan LiuZhongdong HuPengfei TuLuqi HuangXingyun ChaiPublished in: The Journal of organic chemistry (2023)
Three quinone-terpenoid alkaloids, alashanines A-C ( 1 - 3 ), possessing an unprecedented 6/6/6 tricyclic conjugated backbone and quinone-quinoline-fused characteristic, were isolated from the peeled stems of Syringa pinnatifolia . Their structures were elucidated by analysis of extensive spectroscopic data and quantum chemical calculations. A hypothesis of biosynthesis pathways for 1 - 3 was proposed on the basis of the potential precursor iridoid and benzoquinone. Compound 1 exhibited antibacterial activities against Bacillus subtilis and cytotoxicity against HepG2 and MCF-7 human cancer cell lines. The results of the cytotoxic mechanism revealed that compound 1 induced apoptosis of HepG2 cells through activation of ERK.
Keyphrases
- induced apoptosis
- signaling pathway
- bacillus subtilis
- endoplasmic reticulum stress
- molecular docking
- pi k akt
- molecular dynamics
- endothelial cells
- oxidative stress
- cell proliferation
- papillary thyroid
- human health
- electronic health record
- high resolution
- photodynamic therapy
- squamous cell carcinoma
- machine learning
- induced pluripotent stem cells
- breast cancer cells
- silver nanoparticles
- risk assessment
- data analysis
- big data
- squamous cell
- deep learning