Revealing New Prospects: Antipsychotic Drugs Exert Anti-Tumor Effects against Gastric Cancer through Inducing Apoptosis.

Omolbanin Amjadi Akbar Hedayatizadeh-Omran Ehsan Zaboli Ghasem Janbabaee Sergio A Lira Ghasem Ahangari

Published in: Current cancer drug targets (2024)

Through in vitro experiments, this study provides evidence that the antipsychotic drugs cabergoline, dopamine, thioridazine, and entacapone can inhibit gastric cancer growth in AGS and KATO-III cells. These findings suggest that these drugs could be repurposed as novel therapeutic agents for the treatment of gastric cancer.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
oxidative stress
pi k akt
drug induced
signaling pathway
metabolic syndrome
uric acid
combination therapy
smoking cessation