Enantioselective PCCP Brønsted acid-catalyzed aza-Piancatelli rearrangement.
Gabrielle R HammersleyMeghan F NicholHelena C SteffensJose M DelgadoGesine K VeitsJavier Read de AlanizPublished in: Beilstein journal of organic chemistry (2019)
An enantioselective aza-Piancatelli rearrangement has been developed using a chiral Brønsted acid based on pentacarboxycyclopentadiene (PCCP). This reaction provides rapid access to valuable chiral 4-amino-2-cyclopentenone building blocks from readily available starting material and is operationally simple.