Detrimental effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol leads to a specific bio-behavioural profile in adult male rats.

Nafsika PouliaFoteini DelisCharalampos BrakatselosAlexia PolissidisYassemi KoutmaniNikolaos Kokras Christina DallaPanagiotis K PolitisKaterina Antoniou

Published in: British journal of pharmacology (2021)

Our adolescent low-dose THC animal model does not induce tangible psychotic-like effects, such as those reported in high-dose THC studies, but it impairs cognitive functions and points to hippocampal vulnerability and disrupted neurogenesis.

Keyphrases

low dose
high dose
young adults
mental health
childhood cancer
stem cell transplantation
cerebral ischemia
bipolar disorder
climate change
resting state
functional connectivity