Interplay Between Zero CAC, Quantitative Plaque Analysis, and Adverse Events in a Diverse Patient Cohort.
Michael FattouhToshiki KunoPamela Piña SantanaJohn P SkendelasDaniel LorenzattiJavier ArceJonathan DaichGustavo DuarteCarol Fernandez-HazimMiguel Rodriguez-GuerraPatrick NeshiwatAldo L SchenoneLili ZhangCarlos J RodriguezArmin Arbab-ZadehPiotr J SlomkaSalim S ViraniMichael J BlahaDaniel S BermanDamini DeyMario J GarciaLeandro SlipczukPublished in: Circulation. Cardiovascular imaging (2023)
In summary, no sex, race, or ethnicity differences were demonstrated in the negative predictive value of a zero CAC; however, patients with ≥2 risk factors had a higher prevalence of plaque. A small percentage (7%) of symptomatic patients undergoing coronary computed tomography angiography with zero CAC had noncalcified coronary plaque, with the implication that caution is needed for downscaling of preventive treatment in patients with zero CAC, chest pain, and multiple risk factors.