Olaparib enhances sensitization of BRCA-proficient breast cancer cells to x-rays and protons.

Sohee ParkChanghoon Choi Haeyoung KimYong Jae ShinYunjeong OhWon ParkWon Kyung ChoNalee Kim

Published in: Breast cancer research and treatment (2023)

This study found that Olaparib enhanced radiation efficacy in BRCA-proficient breast cancer cells, with a more pronounced effect observed with proton irradiation compared to X-ray irradiation. Combining Olaparib with an ATR inhibitor increased the radiosensitizing effect of protons.

Keyphrases

breast cancer cells
radiation induced
breast cancer risk
magnetic resonance imaging
oxidative stress
mass spectrometry
dna damage
contrast enhanced