A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.

Jiaqin ChenDong FengYuanyuan LuYanjun ZhangHanxiang JiangMan YuanYifan XuJianjun ZouYubing ZhuJingjing ZhangChun GeYing Wang

Published in: Cancers (2023)

Our study comprehensively profiled the anti-hepatoma characteristics and molecular mechanisms of CPUL1, highlighting the implications of progressive metabolic failure. This could partially be ascribed to autophagy blockage, which supposedly conveyed nutritional deprivation and intensified cellular vulnerability to stress.

Keyphrases

signaling pathway
cell death
multiple sclerosis
climate change
oxidative stress
single cell
endoplasmic reticulum stress
rna seq
stress induced