HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism.

Hayrunnisa Bolay BelenÖmer KaradasBilgin OztürkRiza SonkayaBahar TasdelenTuba D S BulutÖzlem GülbaharAynur ÖzgeBetül Baykan

Published in: The journal of headache and pain (2021)

Stronger inflammatory response is associated with headache in hospitalized COVID-19 patients with moderate disease severity. Increased levels of the circulating inflammatory and/or nociceptive molecules like HMGB1, NLRP3, and IL-6 may play a role in the potential induction of the trigeminal system and manifestation of headache secondary to SARS-CoV-2 infection.

Keyphrases

coronavirus disease
inflammatory response
sars cov
respiratory syndrome coronavirus
neuropathic pain
oxidative stress
risk assessment
toll like receptor