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Recurrent Primary Paget Disease of Vulva with Paget-Like Epithelial Cells in Papillary Dermis: Displaced or Invasion?

Steffanie Charlyne TamayoM Ruhul QuddusKamaljeet Singh
Published in: International journal of surgical pathology (2023)
While histological diagnosis of Paget disease of vulva is mostly straightforward, identifying and confirming invasion can be challenging. Often invasion is accompanied by epidermal hyperplasia, marked inflammatory response and desmoplastic reaction. Diagnosis of invasion in Paget disease portends a poor outcome. We report findings from a recurrent primary vulvar Paget disease where overall histomorphology of possible invasive disease is unusual and raises a possibility of displacement of Paget cells in the dermis. We compare histology of the index case with known invasive vulvar Paget disease cases retrieved from our pathology archives. Unique histomorphology in the index case suggests a possibility of previous excision related dermal displacement of Paget cells.
Keyphrases
  • inflammatory response
  • cell migration
  • squamous cell carcinoma
  • oxidative stress
  • radiation therapy
  • cell cycle arrest
  • rectal cancer
  • locally advanced