Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia.

Sverre HolmHassen KaredAnnika Elisabet Michelsen Xiang Yi Kong Tuva Børresdatter DahlNina H SchultzTuula Anneli NymanCathrine FladebyIngebjørg SeljeflotThor UelandMaria StenslandSiri MjaalandGuro Løvik GollLise Sofie Nissen-MeyerPål AukrustKarolina SkagenIda GregersenMona SkjellandPål A HolmeLudvig A Munthe Bente Halvorsen

Published in: European heart journal (2021)

The results show that anti-PF4/polyanion IgG-mediated thrombus formation in VITT patients is accompanied by a massive innate immune activation and particularly the fulminant activation of neutrophils including NETosis. These results provide novel data on the immune response in this rare adenoviral vector-induced VITT.

Keyphrases

immune response
innate immune
high glucose
diabetic rats
end stage renal disease
ejection fraction
newly diagnosed
drug induced
peritoneal dialysis
prognostic factors
endothelial cells
electronic health record
dendritic cells
oxidative stress
patient reported outcomes
patient reported