Hypoxia Modulates Platelet Purinergic Signalling Pathways.
Gordon G PatersonJason M YoungJoseph A WillsonChristopher J GrahamRebecca C DruEleanor W LeeGreig S TorpeySarah R WalmsleyMelissa V ChanTimothy David WarnerJohn Kenneth BaillieAlfred Arthur Roger ThompsonPublished in: Thrombosis and haemostasis (2019)
Our results provide evidence of increased P2Y1 receptor activity at high altitude and suggest down-regulation of the P2Y12 pathway through increased VASP phosphorylation. These changes in ADP pathway activity are of potential therapeutic significance to high-altitude sojourners and hypoxic sea level patients prescribed platelet inhibitors and warrant further investigation.