[6]-Gingerol Ameliorates ISO-Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF-κB Pathway.
Xue HanPanpan LiuMiaomiao LiuZiheng WeiSen FanXiangting WangShijiang SunLi ChuPublished in: Molecular nutrition & food research (2020)
The protective effect of [6]-gingerol in mice with ISO-induced myocardial fibrosis may be related to the inhibition of oxidative stress, inflammation, and apoptosis, potentially through the TLR4/MAPKs/NF-κB signaling pathway.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- induced apoptosis
- ischemia reperfusion injury
- dna damage
- inflammatory response
- toll like receptor
- left ventricular
- pi k akt
- immune response
- high glucose
- nuclear factor
- drug induced
- lps induced
- cell cycle arrest
- mouse model
- heat shock
- cell death
- cell proliferation
- endoplasmic reticulum stress
- liver fibrosis
- skeletal muscle
- endothelial cells
- high fat diet induced
- heat shock protein