Cancer-Associated Fibroblast-Derived IL-6 Determines Unfavorable Prognosis in Cholangiocarcinoma by Affecting Autophagy-Associated Chemoresponse.

Suyanee ThongchotChiara VidoniAlessandra FerraresiWatcharin LoilomeNarong KhuntikeoSakkarn SangkhamanonAttapol TitapunCiro Isidoro Nisana Namwat

Published in: Cancers (2021)

Our data support a therapeutic strategy that includes autophagy-enhancing drugs along with adjuvants limiting the stromal inflammation (i.e., the secretion of IL-6) to improve the survival of CCA patients.

Keyphrases

oxidative stress
cell death
end stage renal disease
endoplasmic reticulum stress
ejection fraction
newly diagnosed
signaling pathway
chronic kidney disease
patient reported outcomes
deep learning
machine learning
free survival