CSF chitinase 3-like 1 is associated with iron rims in patients with a first demyelinating event.

Manuel ComabellaMargareta A ClarkeSabine SchaedelinMar TintoreDeborah ParetoNicolás FissoloRucsanda PinteacCristina GranzieraJaume Sastre-Garriga Pascal BenkertCristina AugerJens KuhleXavier MontalbanAlex Rovira

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

These findings support an important contribution of activated microglia/macrophages to the pathophysiology of chronic active lesions with iron rims in patients with a first demyelinating event.

Keyphrases

iron deficiency
inflammatory response
neuropathic pain
cerebrospinal fluid
drug induced