Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury via cysteine.
Xiaoyan LuNannan WangYuanfang TaoJiamin WangXin JiJinying LiuWeili ZhaoJian ZhangPublished in: Chemical communications (Cambridge, England) (2022)
Herein, by optimizing phenyl selenide-based BODIPYs, BDP-Se-MOS was obtained, which possessed resistance to ROS and could selectively detect Cys. BDP-Se-MOS could not only discriminate between normal and cancer cells, but also image Cys levels in tumor-bearing mice in real time as well as image the fluctuations of Cys levels in an APAP-induced DILI model.
Keyphrases
- quantum dots
- living cells
- drug induced
- deep learning
- papillary thyroid
- room temperature
- high glucose
- fluorescent probe
- dna damage
- reduced graphene oxide
- diabetic rats
- reactive oxygen species
- squamous cell
- single molecule
- emergency department
- highly efficient
- squamous cell carcinoma
- high fat diet induced
- oxidative stress
- endothelial cells
- skeletal muscle
- young adults
- wild type
- insulin resistance