Baicalin Attenuates YAP Activity to Suppress Ovarian Cancer Stemness.

Yucong LiDong WangJingshu LiuYunzhe LiDuke ChenLei ZhouTingyuan LangQi Zhou

Published in: OncoTargets and therapy (2020)

The results in this study demonstrated that baicalin suppresses the stemness of ovarian cancer cells by attenuating YAP activity via inhibiting RASSF6 at the transcriptional level. This finding revealed baicalin as a novel YAP inhibitor that could serve as an anti-cancer drug for eradicating ovarian cancer stem cells.

Keyphrases

cancer stem cells
stem cells
signaling pathway
epithelial mesenchymal transition
gene expression
transcription factor
single cell
drug induced
heat stress