Phage Immunoprecipitation-Sequencing Reveals CDHR5 Autoantibodies in Select Patients With Interstitial Lung Disease.

Vaibhav UpadhyayYoung Me YoonSara E VazquezTania E VelezKirk D JonesCathryn T LeeChristopher S LawPaul J WoltersSeoyeon LeeMonica M YangErica FarrandImre NothMary E StrekMark S AndersonJoseph L DeRisiAnne I SperlingAnthony K Shum

Published in: ACR open rheumatology (2024)

We used PhIP-Seq to define a novel CDHR5 autoantibody in a subset of select patients with ILD. Our data complement a recent study showing polymorphisms in the CDHR5-IRF7 gene locus strongly associated with titer of anticentromere antibodies in systemic sclerosis, creating a growing body of evidence suggesting a link between CDHR5 and autoimmunity.

Keyphrases

interstitial lung disease
systemic sclerosis
single cell
genome wide
rheumatoid arthritis
idiopathic pulmonary fibrosis
rna seq
dendritic cells
electronic health record
copy number
big data
gene expression
dna methylation
cystic fibrosis
genome wide association study
celiac disease