Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg-positive chronic hepatitis B.
Josef WagnerLilly YuenMargaret LittlejohnVitina SozziKathy JacksonRoss MartinThomas AeschbacherVithika SuriSusanna K TanBecket FeierbachAnuj GaggarPatrick MarcellinMaria Buti FerretHarry L A JanssenEd GaneNiamh MeagherDavid J PriceDarren WongAlexander T ThompsonPeter A RevillPublished in: Alimentary pharmacology & therapeutics (2022)
Baseline HN ≤2 predicts which patients with HBV genotypes A or D will more likely progress to functional cure on current direct-acting antiviral therapy, with greater accuracy than current biomarkers including baseline HBsAg and HBeAg titre.