Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium.

Cancan QiJudith M VonkDiana A van der PlaatMaartje A E NieuwenhuisF Nicole Dijknull nullDylan AïssiValérie SirouxH Marike BoezenCheng-Jian XuGerard H Koppelman

Published in: Clinical and translational allergy (2020)

We identified DNA methylation markers possibly associated with clinical and complete asthma remission in nasal brushes and whole blood, and two CpG sites identified from whole blood can be replicated in independent cohorts and may play a role in peroxisome proliferation and Wnt signaling pathway.

Keyphrases

dna methylation
genome wide
signaling pathway
chronic obstructive pulmonary disease
gene expression
lung function
disease activity
allergic rhinitis
chronic rhinosinusitis
pi k akt
stem cells
epithelial mesenchymal transition
systemic lupus erythematosus
rheumatoid arthritis
cystic fibrosis
air pollution