This paper provides an overview of recent developments in the field of volatile organic compound (VOC) sensors, which are finding uses in healthcare, safety, environmental monitoring, food and agriculture, oil industry, and other fields. It starts by briefly explaining the basics of VOC sensing and reviewing the currently available and quickly progressing VOC sensing approaches. It then discusses the main trends in materials' design with special attention to nanostructuring and nanohybridization. Emerging sensing materials and strategies are highlighted and their involvement in the different types of sensing technologies is discussed, including optical, electrical, and gravimetric sensors. The review also provides detailed discussions about the main limitations of the field and offers potential solutions. The status of the field and suggestions of promising directions for future development are summarized.