Anti-TRIM21 antibody is associated with aberrant B-cell function and type I interferon production in systemic lupus erythematosus.

Yosuke KunishitaRyusuke YoshimiReikou KamiyamaDaiga KishimotoTakaaki KomiyaNatsuki SakuraiYumiko SugiyamaKaoru Takase-MinegishiYohei KirinoShouhei NagaokaHideaki Nakajima

Published in: Lupus (2021)

Anti-TRIM21 Ab seropositivity was related to B-cell abnormalities and type I IFN overproduction in SLE patients. These findings suggest that anti-TRIM21 Ab may have an inhibitory effect on TRIM21 functions and be a novel biomarker for the level of dependence on type I IFN overproduction and B-cell abnormalities.

Keyphrases

dendritic cells
immune response
end stage renal disease
systemic lupus erythematosus
ejection fraction
prognostic factors
patient reported outcomes
disease activity