Development of a liver-specific Tet-off AAV8 vector for improved safety of insulin gene therapy for diabetes.
Shu Uin GanZhenying FuKian Chuan SiaOi Lian KonRoy CalneKok Onn LeePublished in: The journal of gene medicine (2019)
The present study provides proof of concept that, under circumstances when inappropriate basal insulin secretion is a safety concern, insulin secretion from AAV8 gene therapy can be turned off reversibly with doxycycline.