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Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.

Alexandra VogelTimo UeberbachAnnett Wilken-SchmitzLisa HahnefeldLuisa FranckMarc-Philipp WeyerTassilo JungenitzTobias SchmidGiulia BuchmannFlorian FreudenbergRalf P BrandesRobert GurkeStephan W SchwarzacherGerd GeisslingerThomas MittmannIrmgard Tegeder
Published in: Cell & bioscience (2023)
The results suggest that ELP may predispose to chronic "pain" and compulsive psychopathology in part mediated by alterations of sphingolipid metabolism, which have been previously described in the context of addiction and psychiatric diseases.
Keyphrases
  • chronic pain
  • early life
  • obsessive compulsive disorder
  • pain management
  • high frequency
  • mental health
  • deep brain stimulation
  • genetic diversity
  • spinal cord
  • spinal cord injury
  • neuropathic pain
  • postoperative pain