Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.
Alexandra VogelTimo UeberbachAnnett Wilken-SchmitzLisa HahnefeldLuisa FranckMarc-Philipp WeyerTassilo JungenitzTobias SchmidGiulia BuchmannFlorian FreudenbergRalf P BrandesRobert GurkeStephan W SchwarzacherGerd GeisslingerThomas MittmannIrmgard TegederPublished in: Cell & bioscience (2023)
The results suggest that ELP may predispose to chronic "pain" and compulsive psychopathology in part mediated by alterations of sphingolipid metabolism, which have been previously described in the context of addiction and psychiatric diseases.