Outcomes of rituximab-BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation.
Deepa JagadeeshNavneet S MajhailYizeng HeKwang W AhnCarlos LitovichSairah AhmedMahmoud AljurfUlrike BacherSherif M BadawyNelli BejanyanMitchell CairoJan CernyNarendranath EpperlaNosha FarhadfarCésar O FreytesRobert Peter GaleBradley HaverkosNasheed HossainDavid InwardsRammurti T KambleVaishalee P KenkreHillard M LazarusAleksandr LazaryanLazaros LekakisMatthew G MeiHemant S MurthyAlberto MussettiSunita NathanTaiga NishihoriRichard F OlssonPraveen Ramakrishnan GeethakumariBipin N SavaniJean A YaredTimothy S FenskeMohamed A Kharfan-DabajaAnna SuredaMehdi HamadaniPublished in: Cancer (2020)
In this large registry analysis of DLBCL patients undergoing auto-HCT, the addition of rituximab to the BEAM conditioning regimen had no impact on transplantation outcomes. Older age, absence of CR pre auto-HCT, and early chemoimmunotherapy failure were associated with inferior survival.