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DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication.

Kevin S PaulsenYanxiang DengAram J Chung
Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2018)
Complex-shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics-based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D-shaped particles in a high-throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on-the-fly fabricated multiscale fluidic channels producing customized sub-100 µm 3D-shaped microparticles. This flexible design scheme offers a user-friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.
Keyphrases
  • tissue engineering
  • high throughput
  • drug delivery
  • low cost
  • human health
  • cancer therapy
  • risk assessment
  • loop mediated isothermal amplification