SARS-CoV-2 invasion of the central nervous: a brief review.
Ruqaiyyah SiddiquiMohammad Ridwane MungrooNaveed Ahmed KhanPublished in: Hospital practice (1995) (2021)
There is increasing evidence of the ability of the novel coronavirus to invade the central nervous system (CNS). But how does a respiratory virus invade the highly protected CNS? Here, we reviewed available literature and case reports to determine CNS involvement in COVID-19, and to identify potential regions of the brain that may be affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible route of entry into the brain to identify its pathogenicity. Based on the symptoms, the parietal lobe and the cerebellum are the likely targets of SARS-CoV-2; however, further work is needed to elucidate this. The presence of ACE2, used by SARS-CoV-2 for cell entry, in the brain as well as detection of the virus in the cerebrospinal fluid, further assert that SARS-COV-2 targets the brain, and therefore, medical practitioners should take that into account when dealing with patients suffering from COVID-19.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- resting state
- white matter
- cerebrospinal fluid
- coronavirus disease
- blood brain barrier
- cerebral ischemia
- end stage renal disease
- primary care
- ejection fraction
- healthcare
- newly diagnosed
- systematic review
- stem cells
- chronic kidney disease
- physical activity
- working memory
- depressive symptoms
- escherichia coli
- multiple sclerosis
- prognostic factors
- cystic fibrosis
- climate change
- bone marrow
- brain injury
- cell therapy
- quantum dots
- human health
- patient reported
- pseudomonas aeruginosa