MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis.

Huiying LuCui ZhangWei WuHuimin Chen Ritian LinRuicong SunXiang GaoGengfeng LiQiong HeHan GaoXiaohan WuJian LinRui-Xin ZhuJianli NiuPappachan E KolattukudyZhan Ju Liu

Published in: Gut (2022)

deficiency polarises macrophages towards M1-like phenotype, arrests macrophage maturation and exacerbates intestinal inflammation in an Atf3-Ap1s2-dependent manner, thus providing novel mechanistic insight into intestinal macrophage functions during IBD.

Keyphrases

transcription factor
oxidative stress
adipose tissue
endoplasmic reticulum stress
dendritic cells
endothelial cells
peripheral blood
replacement therapy
cardiopulmonary resuscitation
cardiac arrest