DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits.
Mengqi WangNathalie BissonnetteMario LaterrièrePier-Luc DudemaineDavid GagnéJean-Philippe RoyMarc-André SirardEveline M Ibeagha-AwemuPublished in: BMC biology (2024)
In conclusion, our findings revealed abundant DNA methylation alterations in milk somatic cells that may be involved in regulating mammary gland defense against S. aureus infection. Particularly noteworthy is the identification of seven dMHBs showing significant associations with mammary gland health, underscoring their potential as promising epigenetic biomarkers. Overall, our findings on DNA methylation alterations offer novel insights into the regulatory mechanisms of bovine subclinical mastitis, providing further avenues for the development of effective control measures.
Keyphrases
- dna methylation
- genome wide
- gene expression
- staphylococcus aureus
- public health
- healthcare
- copy number
- mental health
- induced apoptosis
- health information
- human health
- transcription factor
- health promotion
- cell cycle arrest
- endoplasmic reticulum stress
- cell death
- biofilm formation
- oxidative stress
- methicillin resistant staphylococcus aureus