[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model.

Giacomo PirovanoSheryl RobertsChristian BrandPatrick L DonabedianChristian MasonPaula Demétrio de SouzaGeoff S HigginsThomas Reiner

Published in: Molecular imaging and biology (2020)

[18F]FE-OTS964 is the first TOPK inhibitor for imaging purposes and may prove useful in the continued investigation of the pharmacology of TOPK inhibitors and the biology of TOPK in cancer patients.

Keyphrases

pet imaging
small molecule
high resolution
positron emission tomography
metal organic framework
protein protein
computed tomography
aqueous solution
drug delivery
visible light
fluorescence imaging