BMP8 and activated brown adipose tissue in human newborns.
Adela UrisarriIsmael González-GarcíaÁnxela Estévez-SalgueroMaría P PataEdward MilbankNoemi LópezNatalia MandiáCarmen Grijota-MartinezCarlos A SalgadoRuben NogueirasCarlos DiéguezFrancesc VillarroyaJosé Manuel Fernandez RealMaría L CouceMiguel LópezPublished in: Nature communications (2021)
The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.
Keyphrases
- adipose tissue
- low birth weight
- pregnant women
- insulin resistance
- mesenchymal stem cells
- preterm infants
- high fat diet
- healthcare
- electronic health record
- gestational age
- endothelial cells
- big data
- machine learning
- type diabetes
- metabolic syndrome
- preterm birth
- skeletal muscle
- data analysis
- postmenopausal women
- amino acid