Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma.
Meghan C Ferrall-FairbanksNicholas H ChakiryanBoris I ChobrutskiyYoungchul KimJamie K TeerAnders E BerglundJames J MuleMichelle FournierErin M SiegelJasreman DhillonSeyed Shayan A FalasiriJuan F ArturoEsther N KatendeGeorge BlanckBrandon J ManleyPhilipp M AltrockPublished in: Cancer research (2022)
Assessment of tumor-infiltrating T-cell and B-cell diversity in renal cell carcinoma advances the understanding of tumor-immune system interactions, linking tumor immune ecology with tumor burden, aggressiveness, and patient survival. See related commentary by Krishna and Hakimi, p. 764.