Germline and Somatic mutations in postmenopausal breast cancer patients.
Tauana Rodrigues NagySimone MaistroGiselly EncinasMaria Lucia Hirata KatayamaGlaucia Fernanda de Lima PereiraNelson Gaburo-JúniorLucas Augusto Moysés FrancoAna Carolina Ribeiro Chaves de GouvêaMaria Del Pilar Estevez DizLuiz Antonio Senna LeiteMaria Aparecida Azevedo Koike FolgueiraPublished in: Clinics (Sao Paulo, Brazil) (2021)
Data obtained indicate that BRCA1/BRCA2 gene testing may be considered for postmenopausal patients with BC who have a family history of cancer. Although some of them are not considered pathogenic, somatic variants of PIK3CA are frequently observed in BC patients, especially in postmenopausal patients.