Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer.

John B Tucker Sarah C Bonema Rebeca García-Varela Ryan A Denu Yang Hu Stephanie M McGregor Mark E Burkard Beth A Weaver

Published in: Cancer research communications (2023)

We surveyed the single-cell landscape of mitotic defects that generate CIN in primary and metastatic breast cancer and relevant models. Misaligned chromosomes predominate, and are less immunostimulatory than other chromosome segregation errors.

Keyphrases

metastatic breast cancer
single cell
copy number
rna seq
high throughput
cell cycle
patient safety
adverse drug
breast cancer risk