SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.

Constantinos Kurt WibmerFrances AyresTandile HermanusMashudu MadzivhandilaPrudence KgagudiBrent OosthuysenBronwen E LambsonTulio de OliveiraMarion VermeulenKarin van der BergTheresa RossouwMichael T BoswellVeronica UeckermannSusan MeiringAnne von GottbergCheryl CohenLynn Morris Jinal N Bhiman Penny L Moore

Published in: Nature medicine (2021)

SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.

Keyphrases

sars cov
respiratory syndrome coronavirus
binding protein
protein protein
coronavirus disease
amino acid
electronic health record
copy number
machine learning
current status
dna binding
deep learning
genome wide