Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed-oral bacteria and high-fat diet using the collaborative cross mouse model.

Luna KarkarHanifa J Abu-Toamih AtamniAsal MilhemYael Houri-HaddadFuad A Iraqi

Published in: Animal models and experimental medicine (2020)

This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance.

Keyphrases

insulin resistance
high fat diet
type diabetes
metabolic syndrome
adipose tissue
mouse model
high fat diet induced
weight loss
skeletal muscle
genome wide
weight gain
glycemic control
copy number
quality improvement
physical activity