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Early-life adversity severity, timing, and context type are associated with SLC6A4 methylation in emerging adults: Results from a prospective cohort study.

Stephanie M KoningCourtenay L KesslerTurhan CanliElif A DumanEmma K AdamRichard ZinbargMichelle G CraskeJacquelyn E StephensSuzanne Vrshek-Schallhorn
Published in: Psychoneuroendocrinology (2024)
Results further implicate epigenetic modification on serotonergic neurotransmission via DNAm in the downstream sequelae of ELA-particularly adolescent deprivation-and support preventive interventions in adolescence to mitigate biological embedding.
Keyphrases
  • early life
  • dna methylation
  • young adults
  • depressive symptoms
  • genome wide
  • mental health
  • gene expression
  • physical activity
  • nk cells
  • childhood cancer