H 2 O 2 -driven enzymatic oxyfunctionalization of tertiary C-H bonds.

Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc ., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.