Metagenomic Next-Generation Sequencing for Pathogen Detection and Transcriptomic Analysis in Pediatric Central Nervous System Infections.

Nanda RamchandarNicole G CoufalAnna S WardenBenjamin BriggsToni SchwarzRita StinnettHeng XieRobert SchlabergJennifer FoleyChristina ClarkeBryce WaldemanClaudia EnriquezStephanie OsborneAntonio ArrietaDaria SalyakinaMichelin JanvierPrithvi SendiBalagangadhar R TotapallyDavid DimmockLauge Farnaes

Published in: Open forum infectious diseases (2021)

Metagenomic sequencing of CSF has the potential to rapidly identify pathogens in children with CNS infections.

Keyphrases

antibiotic resistance genes
cerebrospinal fluid
young adults
blood brain barrier
single cell
copy number
candida albicans
gram negative
gene expression
microbial community
risk assessment
antimicrobial resistance
human health
real time pcr
cell free