Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats.

Abubakar Sha'abanHadzliana ZainalNor Azlina KhalilFatimatuzzahra' Abd Aziz Ch'ng Ewe Seng Chin-Hoe Teh Mustapha MohammedBaharudin Ibrahim

Published in: Molecules (Basel, Switzerland) (2022)

The study identified metabolic signatures that correlated with the development of a low-dose Aspirin-induced gastric toxicity in rats. This pharmacometabolomic approach could further be validated to predict LDA-induced gastric toxicity in patients with coronary artery disease.

Keyphrases

low dose
high glucose
diabetic rats
oxidative stress
high dose
type diabetes
endothelial cells
antiplatelet therapy
cardiovascular disease