Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma.

Hong Kyu LeeMi Jung KwonYong Joon RaHee Sung LeeHyoung Soo KimEun Sook NamSeong Jin ChoHye-Rim ParkSoo Kee MinJinwon SeoJi-Young ChoeKyueng-Whan MinSo Young Kang

Published in: Diagnostic pathology (2020)

PIK3CA mutation may be an alternative prognostic biomarker in PD-L1-negative curatively resected ESCCs that can be optional to identify high-risk patients with worse clinical outcome who require more intensive therapy and follow-up.

Keyphrases

lymph node
wild type
prognostic factors
protein kinase
high grade
metastatic colorectal cancer
mesenchymal stem cells