Microvesicles released from activated CD4 + T cells alter microvascular endothelial cell function.
Daria VdovenkoCarolina BalbiDario Di SilvestreGiulia PassignaniYustina M PuspitasariMartina Zarak-CrnkovicPierluigi MauriGiovanni G CamiciThomas F LüscherUrs ErikssonGiuseppe VassalliPublished in: European journal of clinical investigation (2022)
T cells stimulates the release of microvesicles enriched with proteins involved in immune responses, inflammation and apoptosis. T cell-derived microvesicles alter microvascular endothelial function and barrier permeability, potentially promoting tissue inflammation.