Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
Michaela R AndersonImaani EasthausenGrace GallagherJayaram UdupaYubing TongDrew TorigianJoshua Matthew DiamondMary Katherine PorteousScott M PalmerLaurie D SnyderLuke BenvenutoMeghan AversaSelim ArcasoyJohn R GreenlandSteven R HaysJasleen KukrejaEdward CantuJohn Shinn KimDympna GallagherMatthew R BaldwinR Graham BarrDavid J LedererJason D ChristieJonathan Paul SingerPublished in: Thorax (2020)
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.
Keyphrases
- body composition
- skeletal muscle
- insulin resistance
- dual energy
- computed tomography
- contrast enhanced
- image quality
- resistance training
- bone mineral density
- positron emission tomography
- magnetic resonance imaging
- adipose tissue
- high resolution
- type diabetes
- mass spectrometry
- physical activity
- body mass index
- weight gain