Genome-Wide Profiling of the Toxic Effect of Bortezomib on Human Esophageal Carcinoma Epithelial Cells.

Nannan AoYingchu DaiQianping ChenYang FengJingping YuChang WangFenju LiuMing LiGeng Liu

Published in: Technology in cancer research & treatment (2020)

Bortezomib could suppress cell viability, cause G2/M arrest, and induce apoptosis in human esophageal cancer cells, with possible targets including UBD, CUL3, HDAC6, and GADD45A.

Keyphrases

endothelial cells
cell cycle arrest
genome wide
induced apoptosis
multiple myeloma
induced pluripotent stem cells
oxidative stress
cell death
endoplasmic reticulum stress
dna methylation
newly diagnosed
single cell
cell cycle
gene expression