Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system: Effect of opioids.
Esben Bolvig MarkMette Winther KlingeDebbie GrønlundJakob Lykke PoulsenVincent SchlageterS Mark ScottSøren Schou OlesenAsbjørn Mohr DrewesPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)
Oxycodone treatment impaired colonic motility, manifested as increased transit time, specifically decreased long fast antegrade movements, and addition of naloxegol improved motility dynamics. In humans, the increased transit time during opioid treatment is caused by a decrease in long fast movements rather than uncoordinated peristalsis.